Posing Guide 1 Motifs By Design
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: USA Product details: Pesach service with a Twist: A 15 inch diameter lazy susan, painted by hand in a beautiful Kakadu art motif, with six glass bowls. The platter turns smoothly on a ball-bearing mechanism. The bowls measure about 3 1/2 inches across with 1/2 cup capacity, and rest snugly in the mahogany platter's laser-cut openings. Bowls are machine washable. Also suitable for serving fruit, nuts, tapas, dips, and more.
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This item is available in the following motifs: Motif: Delivery Time: Price: Quantity: Autumne $120.00 Climbing Pomegranate $120.00 Composi $120.00 Dream Field $120.00 Harvest $120.00 Ikat $120.00 Lumina $120.00 Mati $120.00 Modernini $120.00 Pomegranate $120.00 Pose $120.00 Yellow Path $120.00 Zipi $120.00.
Biography Nicholas A. Meanwell received his Ph.D. Degree from the University of Sheffield and conducted postdoctoral studies at Wayne State University before joining Bristol-Myers Squibb in 1982. He has been associated with the discovery of BMY-433771, an inhibitor of respiratory syncytial virus fusion, the HIV-1 attachment inhibitor prodrug fostemsavir, the HIV-1 maturation inhibitor BMS-955176, and the marketed HCV inhibitors asunaprevir (NS3, Sunvepra), daclatasvir (NS5A, Daklinza), and beclabuvir (NS5B). He is the co-recipient of a 2014 PhRMA Research and Hope Award for Biopharmaceutical Industry Research and a 2017 ACS Heroes of Chemistry Award. He was the recipient of the 2015 Philip S.
Portoghese Medicinal Chemistry Lectureship Award and was inducted into the ACS Division of Medicinal Chemistry Hall of Fame in 2015. The electronic properties and relatively small size of fluorine endow it with considerable versatility as a bioisostere and it has found application as a substitute for lone pairs of electrons, the hydrogen atom, and the methyl group while also acting as a functional mimetic of the carbonyl, carbinol, and nitrile moieties. In this context, fluorine substitution can influence the potency, conformation, metabolism, membrane permeability, and P-gp recognition of a molecule and temper inhibition of the hERG channel by basic amines. However, as a consequence of the unique properties of fluorine, it features prominently in the design of higher order structural metaphors that are more esoteric in their conception and which reflect a more sophisticated molecular construction that broadens biological mimesis. In this Perspective, applications of fluorine in the construction of bioisosteric elements designed to enhance the in vitro and in vivo properties of a molecule are summarized.
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